Duffy blood group and its relationship to malaria definition

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duffy blood group and its relationship to malaria definition

Looking for online definition of Duffy blood group in the Medical Dictionary? Want to thank TFD for its existence? Relationship between Duffy blood groups genotypes and malaria infection in different ethnic groups of Choco- Colombia. Duffy blood group system, classification of human blood based on the presence of glycoproteins known as The Duffy antigens also serve as receptors for the malarial parasites Plasmodium knowlesi and P. vivax. definition of blood groups. Two homozygous individuals were defined as a low frequency phenotype K + k- .. The ability of the malaria parasite Plasmodium vivax to invade erythrocytes is P. vivax binds the Duffy blood group antigen through its Duffy-binding protein 1 .. Possible Correlation of Transfusion Transmitted Diseases with Rh type and.

Expression of Duffy antigens Duffy antigens are expressed on many different types of cells. Even Fy a-b- individuals who do not produce Duffy antigens on their RBCs do express Duffy antigens elsewhere, including endothelial cells that line blood vessels, epithelial cells of kidney collecting ducts, lung alveoli, and Purkinje cells of the cerebellum. Duffy antigens are also expressed in the thyroid gland, the colon, and the spleen.

As a chemokine receptor, it binds to the chemicals that are secreted by cells during inflammation and recruits other blood cells to the area of damage. Animal studies suggest that the function of Duffy as a chemokine receptor is not physiologically important because mice that lacked the mouse homolog of the Duffy gene Dfy were not more susceptible to infection than mice that expressed Dfy 7.

Indeed, individuals with the null Duffy phenotype appear to have normal RBCs and a normal immune system. Clinical significance of Duffy antibodies Transfusion reactions Antibodies against the Duffy antigens Fya 8Fyb 9, 10Fy3 1and Fy5 11,12 have all been implicated as the cause of a transfusion reaction.

Anti-Fya is more commonly found in patients who are of African descent in whom the Duffy null phenotype is more common and have sickle cell anemia and therefore may require multiple blood transfusions. Hemolytic disease of the newborn Maternal-fetal incompatibilities within the Duffy blood group system is an uncommon cause of HDN. The disease tends to be mild in nature. The Duffy antigens known to have caused maternal immunization and subsequent hemolytic disease are FyaFyb 17and Fy3 1.

duffy blood-group system: Topics by japancarnews.info

It consists of two exons that span over 1, bp of genomic DNA. The two main alleles, FYA and FYB, differ by a single nucleotide at position G and A, respectively and they likewise encode Fya and Fyb antigens that differ by a single amino acid at residue 42 glycine and aspartic acid, respectively.

duffy blood group and its relationship to malaria definition

Most commonly, a mutation in the promoter region of the FYB allele abolishes the expression of the Duffy glycoprotein in RBCs, but the protein is still produced in other types of cells. Perhaps because the Duffy antigens are expressed in other tissues, these patients do not generally make anti-Fyb or anti-Fy3 The size of the fragments were assessed using the Quantity One software program Bio-Rad as follows: Positive and negative controls were samples of typing now standardized in the laboratory of the Group Health and Community.

Qualitative and quantitative variables were analyzed. Qualitative variables were analyzed by chi square test with the EpiInfo 6.

Obtaining genotypic and allelic frequencies and tests of neutrality and genetic structure were done using the "Genepop" program, version 3. The design of the proposal met with the verbal approval of the local governor of the indigenous community and each individual, or his guardian, who agreed to participate, signed or left their digital fingerprint on the informed consent form.

Individuals diagnosed with malaria received, at no cost, the treatment recommended by Colombian standards. This research was considered to be of minimal risk.

duffy blood group and its relationship to malaria definition

Results Description of the study population: In total, volunteers were studied. The ethnic distribution was: Table 1 shows the general characteristics of the population. The probability value p for the relationship of each analyzed variable sex, age, residence area with the ethnicity variable is indicated Frequency of infection by Plasmodium: Among those with an infection, the frequency of each species was: The parasitemia from P.

By ethnicity, the average parasitemia from P.

The Duffy blood group - Blood Groups and Red Cell Antigens - NCBI Bookshelf

Perhaps this finding partly derives from the small size of the groups and notorious variations that are reflected in the high standard deviations Table 2. No significant relationship was found between the species of Plasmodium and ethnicity.

duffy blood group and its relationship to malaria definition

The frequency of the T allele at the locus in Afro-Colombians was 0. The CC and TT genotypes showed frequency of 0. In the locus, the G allele was found less frequently in Afro-Colombians 0.

11. AB blood type (genetics)

Regarding genotype distribution, the lowest frequency of heterozygote's was found in Afro-Colombians 0. Table 4 details the genotypic and allelic frequencies in each of the populations studied for the loci evaluated.

Meanwhile, in the Amerindian and Mestizo populations there is an excess of heterozygotes at locus In evaluating each locus according to the total population, it was observed that in the locus there is a deficit of heterozygotes while in locus there is an excess of them.

Duffy blood group system

To confirm the above, genetic differences were compared through a tree "Neighbor Joining" NJ and the genetic distance of Cavalli-Sforza. A high degree of genetic differentiation was obtained among the three populations. This means that the gene flow between these two ethnic groups mixed is the smallest in the population structure of La Italia.

The shortest distance was found between Amerindians and Mestizos 0. This is contrary to what happened in Amerindians and Mestizos who were predominantly GA genotype. On the other hand, the Amerindians exhibited a frequency times greater of GG while Mestizos were times more frequently found with AA Fig.

  • Duffy blood group and malaria.
  • Duffy antigen system

The TA haplotype was predominately found in Mestizos. Comparison of the 3 most probable haplotypes ge nerated Harlequin program. Analysis of association of some variables - On comparing the average number of episodes of malaria in the last year by diplotype and ethnicity, there was no statistically significant difference.

duffy blood group and its relationship to malaria definition

However, on analyzing the number of malaria episodes in the same period according to ethnicity, significant differences were found in Mestizos who had a higher average number of episodes of malaria in the last year vs.

Individuals with other diplotypes could be infected by P. The diversity in the population as in the case of age and ethnic composition 25 could influence the presentation of asymptomatic parasitemia.

Nonetheless, at least in the present study, no significant association was found between age and frequency of malarial infection in the differing ethnic groups, so that the relevance of the interaction between age-ethnicity-asymptomatic infections should be more widely explored.

duffy blood group and its relationship to malaria definition

A predominance of the C allele at locus Fy- in Afro-Colombians was observed, but less frequently than those reported in African populations 11 Other investigators have reported low frequency of this allele in Colombian Mestizo populations This is probably due to the Afro- Colombian population has suffered a significant level of miscegenation.

Further analysis of the genotypes of locus 46 confirmed that Afro-Colombian and mixed ethnicity are not in the equilibrium of Hardy Weinberg. The frequency of the G allele in locus predominates in Amerindians, while the frequency of the A allele predominates in Afro-Colombians and Mestizos. Similar data have been reported in individuals from North America Caucasian-AmericansAfrican-Americans, Turkish individuals and Colombians, where the A allele predominates, in contrast to Asian-Americans and Hispanic-American individuals in general in which the G allele predominates 15 One surviving tribe—the Jarawas —live in three jungle areas of South Andaman and one jungle area in Middle Andaman.

The area is endemic for malaria. The causative species is Plasmodium falciparum: Blood grouping revealed an absence of both Fy a and Fy b antigens in two areas and a low prevalence in two others. The incidence of Fya among Ashkenazi Jews is 0. The incidence of Fyb is higher in both groups with frequencies of 0.

In Grande Comore also known as Ngazidja the frequency of the Fy a- b- phenotype is 0. In Iran the Fy a-b- phenotype was found in 3. Recent work has identified a number of additional roles for this protein. Asthma[ edit ] Asthma is more common and tends to be more severe in those of African descent.

There appears to be a correlation with both total IgE levels and asthma and mutations in the Duffy antigen.